发给老马备查:: @9 M0 z/ P! p! @, b" J! v, A5 j
滴水察海(69304838) 15:23:238 e1 v* r K" N3 k! {% } \' E8 w5 h
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱. M, p3 y( O0 O. H j; x' G
吉非替尼和S-1连用的依据! x1 I B: H0 ^$ S5 j
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
1 _9 r- t7 K# b1 p是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
* y N6 S/ ]* F$ h2 ?4 {" ]$ J这样是不是推理出,耐药后,可以用S-1和培美了? L8 T8 W( Y, o# b
结论:% N" V2 l, e6 E8 K5 G4 D
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |