发给老马备查:
% w H" S8 N. [1 D3 `! r滴水察海(69304838) 15:23:23% |0 n, K7 l9 a3 \, M
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
9 W, L$ X: a, M5 w1 }( |4 @吉非替尼和S-1连用的依据" I/ l! n! T3 P4 o9 {5 G3 P
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
+ v8 s" g& T, q: |! R是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达2 t0 D2 E# \: T& i* i* m7 m
这样是不是推理出,耐药后,可以用S-1和培美了?8 R" |- P3 E j% H4 L
结论:; H/ I$ O5 i: h
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |