发给老马备查:* X8 L; p9 D! n6 k& E; V2 E6 f
滴水察海(69304838) 15:23:23
1 B/ u* m% a1 q1 ?* G7 y3 P; f老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 W: c- S1 x6 _- U( t
吉非替尼和S-1连用的依据2 t6 q4 r# i5 m/ \* u8 `. Q
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
/ ]6 R; [3 A2 |+ b" H是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, s( U2 _+ y1 `
这样是不是推理出,耐药后,可以用S-1和培美了?' D8 z) R8 e7 ~5 T2 @, {
结论:
$ R- f7 A( H) b/ \. g如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |